[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$fSCPQBpdyoaVUphWkjAYsgw22hCTkdintFlFoq5gUnr8":3},{"_id":4,"background":5,"bigTextImage":10,"biointegrationMechanism":12,"ifu":31,"pageHero":38,"properties":49,"references":72,"seo":75,"trilayer":77},"silkBridge",{"embed":6,"image":7,"type":8,"video":9},"\u003Cdiv style=\"padding:56.25% 0 0 0;position:relative;\">\u003Ciframe src=\"https:\u002F\u002Fplayer.vimeo.com\u002Fvideo\u002F1204447032?badge=0&autopause=0&player_id=0&app_id=58479\" frameborder=\"0\" allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" style=\"position:absolute;top:0;left:0;width:100%;height:100%;\" title=\"Silkbridge Biointegrative Nerve Guide\">\u003C\u002Fiframe>\u003C\u002Fdiv>",null,"embed",{"desktop":7,"mobile":7},{"content":11,"image":7},"SILKBridge® is a biointegrative nerve guide engineered to advance peripheral nerve repair through the unique capabilities of silk fibroin. Its proprietary Tri-Layer™ architecture and semipermeable wall design provide structural support for axonal growth while enabling cellular infiltration, remodeling, and natural integration with native tissue. Designed to balance mechanical integrity, flexibility, and handling, SILKBridge offers surgeons a soft, off-the-shelf implant intended to support repair with both biologic sophistication and procedural simplicity.",{"content":13,"firstSection":14,"secondSection":22,"title":30},"SILKBridge's proprietary physio-chemistry demonstrates neovascularization\nand native tissue ingrowth combined with optimized enzymatic bioabsorption.\nSILKBridge induces neo-angiogenesis.",{"image1":15,"image2":17,"image3":19,"title":21},{"altText":7,"ref":16},"image-484f3b2d49c01325ef3c17523d1b55255b166603-600x595-jpg",{"altText":7,"ref":18},"image-db2c90f6f6eda20869c265e80819e0e106fb7357-1626x951-jpg",{"altText":7,"ref":20},"image-04521fa9de848f737d1de806a8c285cea62d575f-1000x742-jpg","Unique cellular Environment",{"text1":23,"text2":24,"text3":25,"title":26,"title1":27,"title2":28,"title3":29},"Early cell infiltration, regenerated nerve fibers associated with Schwann cells","Blood vessels with erythrocytes, visible throughout","Regrowing myelinated fibers\norganized in microfascicles, with well-defined axoplasm and wellorganized myelin sheaths","PROPRIETARY PHYSIO-CHEMISTRY","2 WEEKS","4 WEEKS","12 AND 24 WEEKS","New Biointegrative Mechanism of Action 1,2,3,4,5",[32],{"code":33,"date":34,"fileUrl":35,"language":36,"title":37},"SB-Art-IFU-US Rev.0 2026-05","2026-04-29","https:\u002F\u002Fcdn.sanity.io\u002Ffiles\u002Fsqdnxmnq\u002Fproduction\u002F0ca444881affa9dfab7a3361cee122f0893f9f93.pdf","English","Biointegrative Nerve Guide (SILKBridge)",{"background":39,"content":45,"logo":46,"title":48},{"image":40,"type":43,"video":44},{"desktop":41,"mobile":7},{"altText":7,"ref":42},"image-abab23660edc7139c3fc7ad6efb1fa35bcfb3ba3-2000x1353-jpg","image",{"desktop":7,"mobile":7},"Biointegrative nerve guide",{"altText":7,"ref":47},"image-94a2f09e00e088032266f6820c18eaeabaf5cb1f-1200x215-svg","Products",{"properties":50,"title":71},[51,55,58,61,65,68],{"content":7,"fullImage":52,"icon":53,"title":7},true,{"altText":7,"ref":54},"image-08450dffa7f2611dbd76fe74c2ea283f27fe1393-256x56-svg",{"content":7,"fullImage":52,"icon":56,"title":7},{"altText":7,"ref":57},"image-e477bed73c5d94821e7e7991dee025dced077f40-167x174-svg",{"content":7,"fullImage":52,"icon":59,"title":7},{"altText":7,"ref":60},"image-62278152da2cec7045f0881b3d785ebf2638545b-256x121-svg",{"content":62,"fullImage":63,"icon":7,"title":64},"SILKBridge® axial deformation profile at physiological value of stress mimics the behaviour of natural nerves².",false,"TENSION AT THE REPAIR SITE?",{"content":66,"fullImage":63,"icon":7,"title":67},"SILKBridge® protects the growing nerve from compressive stresses","COMPRESSIVE STRESSES?​",{"content":69,"fullImage":63,"icon":7,"title":70},"The multilayered structure of SILKBridge® ensures biomechanical compliance at the implantation site¹.","LACK OF MECHANICAL COMPLIANCE ACROSS THE JOINTS?​\n","SILKBridge® PROPERTIES",{"content":73,"title":74},"1. Data on file.\n2. Fregnan et al. (2020) Preclinical Validation of SILKBridge™ for Peripheral Nerve Regeneration. Front. Bioeng. Biotechnol. 8:835. doi: 10.3389\u002F fbioe.2020.00835\n3. Alessandrino et al. (2019). SILKBridge™: a novel biomimetic and biocompatible silk-based nerve conduit. Biomater. Sci. 7:4112. doi: 10.1039\u002F c9bm00783k\n4. A. Alessandrino, Process for the production of a hybrid structure consisting of coupled silk fibroin microfibers and nanofibers, hybrid structure thus obtained and its use as implantable medical device, WO 2016\u002F067189A1, 2016\n5. Biggi et al. (2020). Characterization of Physical, Mechanical, and Biological Properties of SILKBridge Nerve Conduit after Enzymatic Hydrolysis. ACS Appl. Bio Mater. 2020, 3, 8361−8374 doi: 10.1021\u002Facsabm.0c00613","REFERENCES",{"description":45,"image":7,"title":76},"SilkBridge",{"content":78,"firstSection":79,"image":84,"secondSection":86,"title":91},"The 3D architecture of SILKBridge® shows two working mechanisms in one device. SILKBridge® is specifically designed with the aim for the electrospun components (inner and outer layers made of regenerated silk) to promote cells recruitment and adhesion while the textile component (middle layer made of native silk) stays still to support the natural nerve healing process.",{"content":80,"image":81,"title":83},"provides mechanical strength and stability, supporting tensile loading, suture retention, and resistance to compression.",{"altText":7,"ref":82},"image-889eb36022a0a4c9d40ef358dfcdcfd3d12e8752-400x400-jpg","THE INTERMEDIATE WOVEN CORE ",{"altText":7,"ref":85},"image-7495892cd9f045ccddb4e3b067a21068bdfe2d28-936x963-svg",{"content":87,"image":88,"title":90},"layers are designed promote cell adhesion, resorb faster.",{"altText":7,"ref":89},"image-acd8dc3f5eea4230b5dc7e60909f470fccf17d0e-400x400-jpg","THE INNER AND OUTER ELECTROSPUN ","Tri-Layer design 1,2,3,4,5"]