[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$fvMNwKs9mrm2Q_MEqd95ow0kPa8EfnvWZevl-GigiMOI":3},{"_id":4,"bigTextImage":5,"evidenceInfo":8,"pageHero":21,"publications":30,"seo":62},"evidence",{"content":6,"image":7},"SILKBridge® is supported by a growing body of published scientific evidence evaluating its design, material properties, and biologic performance in peripheral nerve repair. Explore the research behind its silk fibroin matrix, proprietary Tri-Layer™ architecture, and biointegrative approach to repair.",null,{"_type":9,"block1":10,"block2":13,"block3":16,"blockImg":19},"evidenceInfo",{"content":11,"heading":12},"SILKBridge is supported by a growing body of scientific evidence spanning material science, preclinical validation, and clinical experience. This section highlights the research foundation behind the product and the data informing its biointegrative approach to peripheral nerve repair.","Evidence",{"content":14,"heading":15},"Preclinical studies have evaluated SILKBridge across key dimensions of peripheral nerve repair, including structural performance, bioabsorption, cellular infiltration, neovascularization, and support for axonal regeneration. Together, these data help characterize how the device is designed to perform in a biologically active repair environment.","1. PRECLINICAL",{"content":17,"heading":18},"Clinical experience with SILKBridge continues to build the evidence base for its use in peripheral nerve repair. This section highlights emerging clinical data and surgeon experience that help inform the product’s translational relevance and real-world potential.","2. CLINICAL",{"altText":7,"ref":20},"image-47a4dd75cc997f1a820bab46f522c8a6bf197fc3-2000x1500-jpg",{"background":22,"content":28,"logo":7,"title":29},{"image":23,"type":26,"video":27},{"desktop":24,"mobile":7},{"altText":7,"ref":25},"image-7d31dd8ace7ad5fac1360556954c4a42da488f24-2000x1333-jpg","image",{"desktop":7,"mobile":7},"The Science Behind SILKBridge","EVIDENCE",[31,40,47,54],{"_key":32,"abstract":33,"autors":34,"category":35,"file":7,"isDownloadLink":36,"link":37,"subtitle":38,"title":39},"60868caaceee","Silk fibroin (Bombyx mori) was used to manufacture a nerve conduit (SilkBridgeTM) characterized by a novel 3D architecture. The wall of the conduit consists of two electrospun layers (inner and outer) and one textile layer (middle), perfectly integrated...","Fregnan et al. (2020)","PRECLINICAL",false,"https:\u002F\u002Fwww.frontiersin.org\u002Fjournals\u002Fbioengineering-and-biotechnology\u002Farticles\u002F10.3389\u002Ffbioe.2020.00835\u002Ffull","Frontiers in Bioengineering and Biotechnology. 8:835. DOI: 10.3389\u002Ffbioe.2020.00835","Preclinical Validation of SilkBridgeTM for Peripheral Nerve Regeneration",{"_key":41,"abstract":33,"autors":42,"category":43,"file":7,"isDownloadLink":36,"link":44,"subtitle":45,"title":46},"32299f906b80","Alessandrino et al. (2019)","PRECLINICAL ","https:\u002F\u002Fpubs.rsc.org\u002Fen\u002Fcontent\u002Farticlelanding\u002F2019\u002Fbm\u002Fc9bm00783k","Biomater Sci. 2019 Oct 1;7(10):4112-4130. doi: 10.1039\u002Fc9bm00783k. Epub 2019 Jul 30. PMID: 31359013 ","SILKBridge™: a novel biomimetic and biocompatible silk-based nerve conduit",{"_key":48,"abstract":49,"autors":50,"category":43,"file":7,"isDownloadLink":7,"link":51,"subtitle":52,"title":53},"bc2f63285078","The in vitro degradation profile and the cytotoxicity of the degradation products of a silk fibroin (SF)-based nerve conduit (SilkBridge), with a complex three-layered wall architecture comprising both native and regenerated (electrospun) ...","Biggi et al. (2020)","https:\u002F\u002Fpubs.acs.org\u002Fdoi\u002F10.1021\u002Facsabm.0c00613","ACS Applied Bio Materials. 3:8361-8374. DOI: 10.1021\u002Facsabm.0c00613","Characterization of Physical, Mechanical, and Biological Properties of SILKBridge Nerve Conduit after Enzymatic Hydrolysis",{"_key":55,"abstract":56,"autors":57,"category":58,"file":7,"isDownloadLink":7,"link":59,"subtitle":60,"title":61},"2f78691cf349","Peripheral nerve injuries often require bridging when direct repair is not feasible. Nerve autografts are the gold standard, but they can lead to donor site morbidity. Silk fibroin-based nerve conduits, like the novel SILKBridge, offer a promising ...","Politikou O, Frueh FS, Greminger M, et al. (2025)","CLINICAL","https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F39592390\u002F","Journal of the Peripheral Nervous System. 30(1). DOI: 10.1111\u002Fjns.12675 ","Digital nerve reconstruction with a new composite silk fibroin nerve conduit",{"description":28,"image":7,"title":29}]